Free Radical Effects on Membranes by Sadis Matalon

By Sadis Matalon

Present subject matters in Membranes offers a scientific, accomplished, and rigorous method of particular issues appropriate to the research of mobile membranes. each one quantity is a visitor edited compendium of membrane biology. Articles lined within the quantity comprise * offers overviews on biomembranes and the effect their physico-chemical houses have on reactive species reactivity * Focuses is on reactive species and keep an eye on of cell-signaling pathways* Illustrates the concept diverse reactive species can modulate functionality of particular membrane ion channels in several tissues, together with sodium channels, chloride channels, sodium-potassium ATPases and calcium channels in either plasma and intracellular organelle membranes

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Jm = Pm . KP /δ (2) To compare the barrier effect of membranes to the transport of RONS, we compare Pm values with the calculated permeability through an equally thick layer of water, Pw (Eq. (3)) Pw = Dw /δ (3) Table 1 summarizes the reported Pm values for different RONS and the calculated Pm /Pw ratios. A. Nitric Oxide and Oxygen The barrier to ·NO and O2 membrane permeation is very low. It is so low that direct measurements of ·NO or O2 transport across membranes cannot be done, because the aqueous layer at both sides of the membrane offers a higher resistance to ·NO or O2 transport than the membrane itself (see below).

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