Advances in Immunopharmacology. Proceeding of the Fourth by J. W. Hadden (Eds.)

By J. W. Hadden (Eds.)

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Additional info for Advances in Immunopharmacology. Proceeding of the Fourth International Conference on Immunopharmacology, Osaka, Japan, 16–19 May 1988

Example text

In addition, considerable eosinophilia was particularly observed at the end of the study and monocytosis was found at a dose of 25 yg/kg/day during the dosing period. Analysis of lymphocyte subsets in peripheral blood was conducted by a flow cytofluorography using EPICS-V after labeling lymphocyte subsets with the corresponding monoclonal antibodies. As shown in Fig. 2, no remarkable changes in the number of the Β cell population identified by using anti-B cell monoclonal antibody (OX 6) was seen throughout the study.

1 % t o 90% w i t h i n 48 h o u r s ( J o h n s o n , et a l . , m a n u s c r i p t i n p r e p a r a t i o n ) . T h e a b i l i t y o f d i f f e r e n t l i g a n d s t o i n d u c e ACTH p r o d u c t i o n b y l y m p h o c y t e s s u g ­ g e s t s t h a t some f e a t u r e s o f t h e r e s p o n s e may be common o r n o n s p e c i f i c . For e x a m p l e , do C R F a n d L P S b i n d t o t h e same Β c e l l r e c e p t o r o r h a v e common i n t r a ­ c e l l u l a r p a t h w a y s ?

However, patients encounter various adverse effects such as flu-like symptoms (pyrexia, rigors or myalgia), leucopenia, eosinophilia, thrombocytopenia, anemia, immunoreaction in lymphoid tissue, neurobehavioral irregularities and abnormal hepatic functions (elevation of GOT and GPT values in serum) during the course of treatment (Bocci, 1982; Lotze, 1985). These undesirable effects following systemic administration of cytokines were not related to their pharmacological properties which were produced in small concentration on local exposure, but to their systemic response referred as "exaggerated pharmacology" (Galbraith, 1987).

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