A Refinement of the Michelson-Morley Experiment by Kennedy R.J.

By Kennedy R.J.

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Monitoring ● Monitor vital signs, ECG, and neurologic status. ● Maintain strict bed rest. 2Watch for signs and symptoms of bleeding tendency and hemorrhage. 2Monitor patient on Cathflo Activase for GI bleeding, venous thrombosis, and sepsis. ● Evaluate results of clotting studies. Storage ● Store Activase at controlled room temperature before and after reconstitution (if needed); protect from light. ● Refrigerate Cathflo Activase at 2Њ to 30ЊC (36Њ to 86ЊF) for 8 hours after reconstitution (if needed).

Provide updates on drug efficacy. ● Inform parents about adverse effects and subsequent nursing interventions, as appropriate. ● alteplase (tissue plasminogen activator, recombinant) Actilyse , Activase, Activase rt-PA , Cathflo Activase, Lysatec rt-PA Pharmacologic class: Plasminogen activator Therapeutic class: Thrombolytic Pregnancy risk category C Action Causes fibrin-enhanced conversion of plasminogen to plasmin, which in turn Reactions in bold are life-threatening. V. V. V. V. over third hour.

Stool guaiac repeatedly above 4+. May give subsequent doses if: all signs of hepatic failure resolve. Discontinue all further treatment for that course. Begin new course (if warranted) no sooner than 7 weeks after adverse event has ended and patient is discharged. stool guaiac test is negative. 5 mg/dL, or 4 mg/dL or higher in patients with severe volume overload, acidosis, or hyperkalemia. persistent oliguria, urine output below 10 mL/hour for 16 to 24 hours with rising serum creatinine. 2Clinical alert A 18 aldesleukin May give subsequent doses if: serum creatinine is below 4 mg/dL fluid and electrolyte status is stable.

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