By M. Ahearne, Alicia J. El Haj, S. Rauz (auth.), Alicia El Haj, Dan Bader (eds.)
This quantity provides chosen peer-reviewed papers of the eighth foreign convention on phone & Stem phone Engineering (ICCM) 2010 in Dublin. The contributions are written via prime scientists in mobilephone and Stem mobilephone Engineering and the subjects of the papers contain:
Computational telephone Mechanics
Experimental suggestions in mobilephone Mechanics
Molecular and mobilephone Imaging
Cell Matrix Interactions
Mechanotransduction and telephone mechanics
Stem mobilephone area of interest
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Extra info for 8th International Conference on Cell & Stem Cell Engineering (ICCE)
It has been previously shown that the biosynthetic activity of chondrocytes depends on the biophysical stimuli experienced by the cells (5). We also observed greater sGAG accumulation in loaded solid constructs compared to all other groups, but we did not find that loading enhanced matrix accumulation in DCM groups. It was seen that loading enhanced cell proliferation in solid gels at day 42, when compared to FSS constructs (Fig. 1C). Comparable sGAG synthesis rates (sGAG/DNA) between all groups at this time point (Fig.
INTRODUCTION Tissue engineering strategies aim to repair cartilaginous defects through the use of porous scaffold or hydrogel based systems which provide a 3D environment allowing cells to maintain their differentiated phenotype and deposit extracellular matrix (ECM). Agarose hydrogels are commonly used for cartilage tissue engineering applications, as they have been found to support the chondrogenic phenotype and the synthesis of cartilage ECM (1-2). In addition they have been shown to provide a well characterized mechanical environment (3), suitable for investigating cellular responses to biophysical stimuli.
Nat Cell Biol 4:83-90 Saksela O, Moscatelli D, Sommer A, Rifkin DB. (1988) Endothelial cell-derived heparin sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation. J Cell Biol 107:743-751 Raghunath M, Unsold C, Kubitscheck U, Bruckner-Tuderman L, Peters R, Meuli M. (1998) The cutaneous microfibrillar apparatus contains latent transforming growth factor-β binding protein-1 and is a repository for latent TGFβ1. Soc Invest Dermatol 111(4):559-564 Chong H, Vodovotz Y, Cox GW, Barcellos-Hoff MH.